I upgraded from .216 using DM when the beta came out and withoud a wipe
here is my input
-faster botting time
-similar battery life
-all apps work
-2.5 megs of memory
-faster browser, specially on wifi
-can't tether but I couldn't on .216 either
-GPS lock is the same
-no randon reboots, honestly I never had any since .185
-3g reception in al 5 bars but I never had any issues ecept for back in Nov and it was not an OS thing, ATT was playing with their towers

I couple of people indicated the get rem files for all new files but that is not the case for me