Scotty I can't believed you IMed me after posting. I hope I get double beers for that
If snapshotting (is that a real word?) make sure you snapshot after every update, as you don't want your CDO and MAPI32 dlls mismatched (or anything else!).
For those who weren't on the IM with me and Scott
and are interested in DR, the main thing I said was the knottyrope mantra - "Backup the DB", at least once a day. The db is the heart of your BES so you can have as many DR plans and setups as you like but without the DB, you are reactivating x users.