tomcruzner, I had a problem similar to this. It turned out to be a corrupted Outlook file. Are you syncing to Outlook?

With my problem, the first time I did a clean install of Desktop Manager and tried to sync the application just dissappeared. After that everytime I attempted to sync, I would get a Microsoft error, which would shut down Desktop Manager.

If you have this problem, your .PST or .OST file is corrupted. There is a utility called scanpst, which you can find using a search. You can run that against your main .PST or .OST file. Mine is called Outlook.OST (off line file). The file can be found at Documents &Settings/username/Local Settings/Application Data/Microsoft/Outlook.

I ran the utility against that file. It showed errors. I took the repair option, but it didn't fix the problem. I had to remame Outlook.OST to Outlook.Old and then resync all my data from Exchange and it cleaned up the problem.

It has happened once since, but scanpst cleared it up and I haven't seen it since.

I spent many hours last weekend with VZW and RIM support to fix this, but once you know what it is, its easy to fix with one of these two methods. I di this writeup hoping to help someone avoid a lot of pain. Its worth it because the device rocks!