FC6 user here as well. I don't feel that any one distro is "best" as ultimately, it depends on a combination of how you want to use your computer, what you expect of your computer and what you're accustomed to in your computer. All the same basic technologies are there in all distros save package management and any given custom kernel patches. Some distros don't mind inclusion of proprietary and/or IP encumbered stuff such as Sun's Java (not the GPL'd) or MP3 codecs and the like. Fedora doesn't include those things though they are rather trivial to install if you find the right guides. (google for FC6 guide...)

I've been RedHat from the beginning and I'm just comfortable with it.