I am using Ascendo DataVault for last many days and I am really happy with the product. Before selecting the product I tried as many applications (trial versions) of similar kind as possible and finally I selected DataVault. The factors that make this product better than the most are as below:

1. Advanced Encryption Standard (AES) - Strongest in the market. It is not just password protection of the application, it is also data protection.
2. Asks for password even when you synchronize with PC.
3. Synchronization with PC is two-way and extremely efficient.
4. Good user control while Synchronization. You get dialog boxes asking for confirmation of the change.
5. Option for both Tree View & List view. Navigation is much easier with the visual aid offered by the tree.
6. Searching is faster than most of the other applications available.
7. Lots of configurable options.
8. Though you can take advantage of using existing templates but using templates are not mandatory while creating a new entry.
9. Exceptional customer support. Just email your queries ... you will get a reply.