Not 100% sure what you're getting at here to be honest. Yes, apart from wipe & lock a hand-held remotely, you can nuke it remotely (on BES you have option to "Set Password and Lock Handheld" or "Erase Data and Disable Handheld", which AFAIK screws up the handheld OS to stop it functioning. However, I also think that these can be reloaded...)
However, AFAIK if a crook backs up the data fast enough, i.e. while the device is operational, they could restore that to an alternative device come-what-may. If that is a wrong assumption I am sure someone will correct me!
I use Domino and BES, and have implemented the ability to use encrypted messages on the BBs. OK, the users cannot send encrypted mail via BB, but if someone encrypts a message sent TO a BB user they can now read it on the device. AFAIK those messages would be safe come-what-may, as a notes user.id file has to be imported to BB Desktop Manager to make the feature work, but unencrypted messages would be vulnerable to a backup-then-restore-to-alternate-device.
~One thing that is key is to make sure your BB users KNOW to inform admins of lost/stolen devices ASAP.
I also use the password protection on device via policy (also idle time-out password prompt at AND device-in-use password prompt, just so that if a thief keeps pressing keys to stop an idle lockout, the device will still ultimately require a password) and if data is very sensitive, set up duress alerting via policy, teach users how to use it, and make sure you act quickly on duress alerts.
Content protection may be of help to you, I am no expert on it but see thread: Content Protection discussion - Necessary?