Dek--you must have your BB plugged in via a USB cable (or BT connection). Click Synchronize, click Configure, set up your Calendar, Memos(notepad), Tasks, and AddressBook to MS Outlook.
Save, and step back.
If you don't have the latest version of Desktop Manager Version 4.2, Service Pack 1, get it first and install it on your desktop... Where can I download Desktop Manager and / or the Handheld OS? - BlackBerryFAQ