I almost always put my phone in standby mode (hold mute key) before putting it in my pocket and once a week, I will pull the phone out and notice the red light blinking and press the mute key and it won't come out of standby.
I did notice that before upgrading to 220.127.116.11, I used to be able to mash the Send/BB/Esc/End keys a few times and then Mute would wake the phone up, but after upgrading to 18.104.22.168, I have to pull the battery to wake it up.
I've personally had the same issue on two different 8330s with 22.214.171.124. I have the issue described above on 126.96.36.199. I've verified with a 8330-bearing (188.8.131.52) coworker.
Has anyone else experienced this or found a resolution to it?