When I upgraded from .114 to .206 the only thing that changed is my home screen arrangement. That always happens to me, so if there is a way to stop that, let me know.
When I upgraded from .206 to .250 my home screen got rearranged and I had to setup a couple applications. I didn't lose any applications and CropIt, which didn't work on .206 now works on .250.
I haven't had any issues so far with .250, been running for about a 5-7 days. My battery life has been better on .250.
Side note: I updated the firmware on my wireless router (netgear) b/c I was having issues with wifi connection to the BB. No more issues.
Bottom line; upgrades rock!