I have been asking the same questions, and here are some of my thoughts:
1. I think based upon some responses all around this forum, for me I want the qwerty key board but check this thread out: how good is suretype
2. Barjohn posts here and has a thread on his website comparing a 7100 vs the 7250 might also help. His web site is: http://www.barjohn.com/
3. The response that I got when I posted this same question is: more phone then the 7130e, more email then 7250.
4. Lastly as I understand it the 7130e is EVDO (high speed internet) out of the box, and the 7250 requires some work with a VZW's tech, a long and painful process. The 7130e also has a slightly faster processor and 32 megs of additional memory.
Hope this helps,