Is there any other way to select a number of items in email that I would like quickly delete on this device? I currently hold down the #key and roll the thumb wheel to select items for deletion.

I'm looking for a way to do this similiar to holding down the shift key plus arrow down combination on a PC.

I thought holding down the # (shift) key and scroll down on the thumb wheel is similar to PC's holding down the shift key and press arrow down?

True, but I'm looking to use something faster, like the Page Down or End Key to select all text.

If you want to delete all of your messages at once, push trackwheel in and select delete prior. This will get rid of all messages.