The escape button, on-off button and trackwheel click no longer seem to be working.
I can use the enter key instead of trackwheel click but don't seem to have an alterntive for the escape.

Any ideas what may be going wrong or any alternative keys.

Have you tried pulling the battery and letting it reboot? Also, you may need to wipe and reload the OS on the device if it continues to be an issue.

If you have any questions/concerns about wiping /resetting your device check out

Main Page - BlackBerryFAQ

or

Blackberry Tips

I installed the new OS yesterday. Nice blue look. I also opened and cleaned it with a mini blower.
Still no luck. Is "wipe" something different.

Is there any other way to get escape functionality to work except for escape button. Else I have to keep taking battery off to esacpe out of a sub item.