It IS something with the PC but it's definately instigated by the software itself. Something gets corrupt for some reason from time-to-time. Uninstalling it, repairing it, deleting all RIM associated folders and registry entries does not correct the issue as well. You basically have to wipe your PC with a new image to solve this. Another method is renaming your windows profile and logging back in. That seemed to solve it also.
I know i'm not the only one experiencing this as well... Desktop Manager Won't Stay Loaded