MDSE is limited to 5 concurrent I/Os at a time. So the more users you have the more likely you are to run into performance issues.
Like Knotty said, once you hit around 500 users you are going to run into trouble. If your BES is on a VM it is even more important that the database be on a SQL server as the I/O from the BES will effect performance on other VMs as well.
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Technical Engineer III
BES was decommissioned. Currently using iPhones with Lotus Notes Traveler 9.0.
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