In general, I have found that uninstalling applications does not reset my Profiles; HOWEVER, sometimes, uninstalling applications that inject themselves into your Profiles can.
For example, BB Alerts, AlertMatrix, FindIt!, Mobylo! MultiAlarm and Viigo to name a few, inject lines into your Profiles (so that you can set sounds for various events within each Profile). When you uninstall those applications, it removes the lines from each of your profiles. Personally, I have found it to be a 50/50 chance that my profiles will get reset to default or not.
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-Klotar
Supervising Manager of the Department of Redundancy Department.
BlackBerry Certified Support Specialist
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