PM responded to... however for public sake, here you go.
RIM's recommendation would have been based on a single configuration database for you with each remote site having their own BES server connected back to it.
Your configuration should really follow a guideline of where your Exchange servers reside. Does each site have its own Exchange server (based on RIM's recommendation, I would assume this is the case)? If so, place a BES in each site. If all Exchange mailboxes come back to your HQ, then you will need only one BlackBerry domain (in the HQ). As for the placement of the database(s), I would say this depends on not just the latency between the remote offices and HQ, but also the network stability. Do some trending analysis over the last few months and see how many times, if at all, connectivity has been lost between the sites. If it's fairly frequent (or far less than 100% uptime), I would recommend configuring the databases local to the BES (separate BlackBerry domains), possibly even looking into configuring individual BlackBerry service accounts in each of those sites.
If you end up doing this, the tricky part is to configure batch scripts to manage each BlackBerry domain. If you decide to go this route, let me know and I'll make available my batch files we use to manage each of our BlackBerry sites. If you have Citrix deployed, it would be very easy to configure published applications for each managed BlackBerry site, as well.
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