Welcome to the forums,
There are a couple things to try.
First make sure you're not plugging into a hub. The BB needs to be connected directly to the computer.
Second, make sure that the computer is not powering off the device. Go to device manager in WinXP and go to Universal Serial Bus Controllers. Then for each instance of USB Root Hub make sure under Power Management that the box that says "allow the computer to turn off the device to save power" is not checked.
If that doesn't work, then you may need to do a complete
removal of
Desktop Manager and reinstall it. Use the latest version 4.2 available at blackberry.com.
Hope this helps...