In case anyone reads this looking for a solution, Mapquest emailed me stating that the issue with calls clicking and losing sound etc is a known issue that is on slate to be resolved in the next release. No ETA on when that will be.
As for the lack of GPS connectivity, they told me that the unit must be in direct line with the Sattelite and that lots of things can interfere with connectivity. Got the standard "restart" the device answer on that.
Where is the ctrl-alt-del button on a blackberry?